Custodiol^® HTK Solution

Bretschneider's Custodiol^® HTK solution for Cardioplegia
and mult-organ protection.

Download Custodiol^® HTK Data Sheet

Download Custodiol^® HTK Brochure on Organ Preservation and Protection

HTK Solution for Multi-Organ Preservation and Protection

HTK (Histidine-Tryptophan-Ketoglutarate) Solution is used by Leading Transplant Centers
worldwide for the preservation of the Kidney, Liver, Heart, Lung and Pancreas during
organ transplantation. Custodiol^® is approved by the US FDA as a Medical Device.

Indications of Custodiol^® (HTK solution) include cardioplegia, organ protection and surface
cooling of the heart, liver and kidney in situ as well as for transportation of organs from donor
to recipient. Custodiol^® solution is also used for the protection of the venous transplants
(coronary vessel replacement,mainly of the great saphenous vein).


In-situ protection

Due to high systemic tolerance all kinds of operation procedures in ischemic organs may be
perfomed such as heart surgery, kidney tumor resection and split liver donation.


Transplantation

Multi organ procurement using Custodiol^® HTK solution

• Reliable preservation of donor organs
• Easier handling due to simultaneous in-situ perfusion of all organs
• Increased organ availability due to excellent postoperative function, even with kidney
  of non-heart beating donors

Autologous graft protection with Custodiol^® HTK solution

• Excellent preservation of venous and arterial grafts
• Reduced rise in permeability of the endothelial cell layer
• Effective even at room temperature

Custodiol^® HTK solution for Cardiac surgery and Transplantation

• High rate of spontaneous return to sinus rhythm
• Minimized cell necrosis
• Less depletion of ATP stores
• Remarkably increased protective potency

Liver Transplantation with Custodiol^® HTK solution

• Extended cold preservation time
• Better preservation of micro-circulation
• Low degree of cell edema
• Prevention of leukocyte adhesion
• Reduced biliary tract complications

Kidney Transplantation with Custodiol^® HTK solution

• Rapid graft function
• Prolongation of ischemic tolerance
• Lower frequency of post-operative dialysis
• Shortened hospitalization
• Good Structural protection even at 25°C
• High rate of long time graft survival

Lung Transplantation with Custodiol^® HTK solution

• Good pulmonary tissue preservation in conjunction with prostaglandins, excellent
  postoperative functional result
• Low post-transplant pulmonary edema
• Good preservation of combined heart-lung graft

Pancreas Transplantation with Custodiol^® HTK solution

• Good endocrine and exocrine function of pancreatic tissue post-operatively
• Suitable for in-situ flush of human pancreases prior to subsequent islet isolation,
  culture and transplantation
• Reliable graft function in a porcine model after up to 24 hours cold storage

Properties of Custodiol^® HTK solution

• Low potassium concentration to minimize risks
• Low sodium concentration for safe organ inactivation
• Extended buffer capacity only possible with high histidine / histidine-Hcl concentration
• Tryptophane supports membrane integrity
• Alpha-ketoglutarate serves as a substrate for aerobic energy production during the
  induction of cardioplegia, and when restarting the heart
• HTK is perfused as a cold solution, so that its hypothermic effect contributes to a
  decreased metabolic rate
• All components of HTK solution are naturally occurring physiological substances except
  for the inert mannitol, therefore no toxic effects have ever been observed

Advantages of Custodiol^® HTK solution

• Use in-situ and during hypothermic storage
• Rapid homogenous cooling due to low viscosity
• Superior recovery of function
• Excellent ischemic tolerance
• High buffering capacity
• Easier surgical handling due to excellent visibility
• Reduced risk of post-aggression syndrome
• Virtual absence of side effects
• Simple perfusion technique (ready-to-use, no additives or preparation) saves cost of
  filters, additives and staff time
• Shortened postoperative intensive care period

Presentation of Custodiol^® HTK solution

• 5 litre bag (cartons of 2 bags)
• 2 litre bag (cartons of 4 bags)
• 1 litre bag (cartons of 6 bags)

Storage:       8 - 15°C


Shelf-Life:       1 year

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