Custodiol^® HTK Solution

Bretschneider's HTK (Histidine Tryptophan Ketoglutarate) solution for
Cardioplegia and Multiple organ protection.

Download Custodiol^® HTK Data Sheet

Custodiol^® HTK (Histidine-Tryptophan-Ketoglutarate) Solution has been used as
a Cardioplegia Solution in 2 million Cardiac Surgery cases by some of the leading
Cardiac Centers Worldwide.


Properties of Custodiol^® HTK solution

• Low potassium concentration to minimize risks
• Low sodium concentration for safe organ inactivation
• Extended buffer capacity only possible with high histidine / histidine-Hcl concentration
• Tryptophane supports membrane integrity
• Alpha-ketoglutarate serves as a substrate for aerobic energy production during the
  induction of cardioplegia, and when restarting the heart
• HTK is perfused as a cold solution, so that its hypothermic effect contributes to a
  decreased metabolic rate
• All components of HTK solution are naturally occurring physiological substances,
  therefore no toxic effects have ever been observed

Advantages of Custodiol^® HTK solution

• Rapid homogenous cooling due to low viscosity
• Superior recovery of function
• Excellent ischemic tolerance
• High buffering capacity
• Easier surgical handling due to excellent visibility
• Virtual absence of side effects
• Simple perfusion technique (ready-to-use, no additives or preparation) saves cost
  of medical disposables, additives and staff time
• Shortened postoperative intensive care period

Presentation of Custodiol^® HTK solution

• 5 litre bag (cartons of 2 bags)
• 2 litre bag (cartons of 4 bags)
• 1 litre bag (cartons of 6 bags)

Storage:       8 - 15°C


Shelf-Life:       1 year